Index: tests/test_tifffile.py
--- tests/test_tifffile.py.orig
+++ tests/test_tifffile.py
@@ -224,7 +224,7 @@ def skip(key: str, default: bool) -> bool:
 
 
 # skip tests requiring large memory
-SKIP_LARGE = skip('SKIP_LARGE', sys.maxsize < 2**32)
+SKIP_LARGE = skip('SKIP_LARGE', True)
 SKIP_EXTENDED = skip('SKIP_EXTENDED', False)
 # skip public files
 SKIP_PUBLIC = skip('SKIP_PUBLIC', not os.path.exists(PUBLIC_DIR))
